Skip to content
Back

Monika Wimmer, PhD

Postdoc

Contact

Scientific interest

Our group is interested in mechanisms of epigenetic regulation in EB. We strive to deepen our understanding of cellular processes promoting the development of a particularly aggressive form of squamous cell carcinoma affecting our patients.
In particular, we are interested in short non-coding RNAs (miRNAs) that are deregulated in RDEB. We aim to identify such miRNAs that have the potential to serve as biomarkers, or that can be used as therapeutic targets. Our goal is to demonstrate an association of de-regulated miRNAs and an aggressive phenotype of cancer cells via functional assays. On the long term, we strive to translate our improved understanding of pathomechanisms into new therapeutic options based on small molecules.

Personal interests

In my spare time I love to be in the mountains.

Curriculum Vitae Monika Wimmer

Professional career

Since 2015
Scientific Associate at the EB House Austria, Working Group Wally
 

Education

2016 - 2020
PhD studies natural sciences, Molecular Biology, Paris Lodron University Salzburg
Working title: “Identifying miRNA key players shaping epidermolysis bullosa”
FWF Research project: P 29343-B30, project leader: Assoc.-Prof. Verena Wally, PhD
Supervisor: Univ.-Prof. Prim. Dr. Johann Bauer, MBA; Assoc.-Prof. Verena Wally, PhD; ao.Univ.-Prof. Dr. Hannelore Breitenbach-Koller

2013-2016
Master studies of Molecular Biology, Faculty of Natural Sciences, University of Salzburg and Johannes Kepler University of Linz
Working title: Post-transcriptional regulation as a disease modifier in recessive dystrophic epidermolysis bullosa
Supervisor: Univ.-Prof. Prim. Dr. Johann Bauer, MBA, Dr. Verena Wally

2010-2013
Bachelor studies of Molecular Biology, Faculty of Natural Sciences, University of Salzburg and Johannes Kepler University of Linz

 

International Research Experience

2014
Garvan Institut, Institute of Neuroscience / Sydney, Australia

 

Awards and Fellowships

2014 Abroad Fellowship - Paris Lodron University Salzburg
2013 Excellence Scholarship - Paris Lodron University Salzburg

 

Additional Qualifications and Trainings

2017 Workshop - Electron Microscope Techniques at the Paris Lodron University Salzburg
2017 Laboratory Animal Science - Basic Course Kurs, Central Animal Laboratories of the Paris Lodron University Salzburg

Original articles

  1. Brunner SM, Ramspacher A, Rieser C, Leitner J, Heil H, Ablinger M, Tevini J, Wimmer M, Koller A, Piñón Hofbauer J, Felder TK, Bauer JW, Kofler B, Lang R, Wally V. Topical Diacerein Decreases Skin and Splenic CD11c(+) Dendritic Cells in Psoriasis. International journal of molecular sciences 2023;24.
  2. Illmer J, Zauner R, Piñón Hofbauer J, Wimmer M, Gruner S, Ablinger M, Bischof J, Dorfer S, Hainzl S, Tober V, Bergson S, Sarig O, Samuelov L, Guttmann-Gruber C, Shalom-Feuerstein R, Sprecher E, Koller U, Laimer M, Bauer JW, Wally V. miR-200b-mediated reversion of a spectrum of epithelial to mesenchymal transition states in recessive dystrophic epidermolysis bullosa squamous cell carcinomas. The British journal of dermatology 2023.
  3. Zauner R, Wimmer M, Atzmueller S, Proell J, Niklas N, Ablinger M, Reisenberger M, Lettner T, Illmer J, Dorfer S, Koller U, Guttmann-Gruber C, Hofbauer JP, Bauer JW, Wally V. Biomarker Discovery in Rare Malignancies: Development of a miRNA Signature for RDEB-cSCC. 2023;15:3286.
  4. Welponer T, Weber DD, Trattner L, Tockner B, Aminzadeh-Gohari S, Leb-Reichl V, Kaufmann A, Zauner R, Wimmer M, Wally V, Felder TK, Strunk D, Koller U, Bauer JW, Kofler B, Guttmann-Gruber C, Piñon Hofbauer J. Metformin shows anti-neoplastic properties by inhibition of oxidative phosphorylation and glycolysis in epidermolysis bullosa-associated aggressive cutaneous squamous cell carcinoma. Journal of the European Academy of Dermatology and Venereology : JEADV 2023
  5. Zauner R, Wimmer M, Dorfer S, Ablinger M, Koller U, Piñón Hofbauer J, Guttmann-Gruber C, Bauer JW, Wally V. Transcriptome-Guided Drug Repurposing for Aggressive SCCs. International journal of molecular sciences 2022;23:1007
  6. Ablinger M, Lettner T, Friedl N, Potocki H, Palmetzhofer T, Koller U, Illmer J, Liemberger B, Hainzl S, Klausegger A, Reisenberger M, Lambert J, Van Gele M, Desmet E, Van Maelsaeke E, Wimmer M, Zauner R, Bauer JW, Wally V. Personalized Development of Antisense Oligonucleotides for Exon Skipping Restores Type XVII Collagen Expression in Junctional Epidermolysis Bullosa. 2021;22:3326.
  7. Wimmer M, Zauner R, Ablinger M, Piñón-Hofbauer J, Guttmann-Gruber C, Reisenberger M, Lettner T, Niklas N, Proell J, Sajinovic M, De Souza P, Hainzl S, Kocher T, Murauer EM, Bauer JW, Strunk D, Reichelt J, Mellick AS, Wally V. A cancer stem cell-like phenotype is associated with miR-10b expression in aggressive squamous cell carcinomas. Cell Commun Signal 2020;18:61
  8. Sun Y, Woess K, Kienzl M, Leb-Reichl VM, Feinle A, Wimmer M, Zauner R, Wally V, Luetz-Meindl U, Mellerio JE, Fuentes I, South AP, Bauer JW, Reichelt J, Furihata T, Guttmann-Gruber C, and Piñón Hofbauer J. Extracellular vesicles as biomarkers for the detection of epidermolysis bullosa-associated squamous cell carcinoma. Journal of Investigative Dermatology 2017;137(10). 
  9. Stoehr LC, Madl P, Boyles MSP, Zauner R, Wimmer M, Wiegand H, Andosch A, Kasper G, Pesch M, Lütz-Meindl U, Hily M, Duschl A. Enhanced Deposition by Electrostatic Field-Assistance Aggravating Diesel Exhaust Aerosol Toxicity for Human Lung Cells. Environmental Science & Technology 2015;49(14):8721-30.

Reviews

  1. Ablinger M, Wally V, Zauner R, Wimmer M. Erforschung von miRNAs bei aggressiven Plattenepithelkarzinomen. Spectrum Dermatologie 2021;01:21-5.
Back to main navigation