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Dr Krisztina Ötvös

Research associate

EB-Haus Forschungsmitarbeiterin

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Research interest

Recessive dystrophic epidermolysis bullosa (RDEB) is a rare skin disease in which aggressive squamous cell carcinomas occur frequently with currently only very limited treatment options. In our research program, we strive to find new or already known drug candidates for use against cancer for our patients. The possibility of “repurposing” already known drugs are also being investigated in order to ensure the shortest possible development times and to be able to access already known safety profiles. In the course of our research, we will also gain further insights into the processes and processes of tumor cells, which will provide the basis for new therapeutic methods.

 

 

Personal interests

Running, reading, enjoying time in nature and with the family.

 

Curriculum Vitae Krisztina Ötvös

Professional experience

Since November 2024
Research associate: EB Haus Austria
Program: Drug Discovery & Repurposing

December 2021 – May 2024
Researcher/Head of NGS R&D: Procomcure Biotech GmbH, Bergheim, Austria
Project: NGS product development

June 2019 – November 2021
Researcher: Austrian Institute of Technology (AIT), Tulln an der Donau, Österreich
Project: Pharmacophore-Screen project

April 2013 – January 2019
Researcher: Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria
Project: innovative developmental biology project

January 2009 – February 2013
Researcher: Umeå Plant Science Center (UPSC), Umeå, Sweden
Project: „Chromatin remodeling“ in the field of developmental biology

September 2006 – December 2011
Researcher: Biological Research Center (BRC), Szeged, Hungary
Project: several projects in the field of developmental biology

 

Academic education

2000 – 2006
PhD Studies: Molecular and Cell Biology, University of Szeged, Szeged, Hungary
Theme of the thesis: cell-cycle regulation, de-novo organogenesis, embryogenesis

1995 – 2000
MSc Studies: Biology, University of Szeged and University of Szeged Albert Szent-Györgyi Medical Faculty, Szeged, Hungary
Theme of the thesis: atrial fibrillation, antiarrhythmics, ion-channels

 

Awards/Fellowships

2017 - Sweden - OlChemIm Poster Award
2011-2012 - Sweden – Carl-Trygger-Foundation, Fellowship
2008 - Hungary – Fellowship for Young Researcher
2006 - Hungary – Scientia Amabilis Fellowship
1997 – 1998 - Hungary – National Excellence-Program
Since 2008 Member of the Hungarian Academy of Sciences‘ Public Body

 

Courses/Certificates

2024 - FELASA B Certificate (mice/rat) – Humboldt University, Berlin, Germany
2024 - Certified Data Analytics Expert with Minitab – Accredited, Udemy
2024 - Six Sigma Foundations – Accredited, LinkedIn Learning
2024 - Quality Management for Operational Excellence – Accredited, LinkedIn Learning
2024 - Quality Management Foundations – Accredited, LinkedIn Learning
2024 - Career Essentials in Project Management by Microsoft and LinkedIn – Accredited, LinkedIn Learning
2024 - Project Management Foundations – PMP accredited, LinkedIn Learning
2024 - Certificate of Basic Good Manufacturing Practices (GMP) - Udemy
2024 - Certificate of Design and Interpretation of Clinical Trials - Johns Hopkins University
2023 - Training Certificates of Illumina Sequencers (NovaSeq X Plus, MiSeq Dx) – Austria
2022 - Training Certificate of Fluent Control, Tecan – Switzerland
2022 - Training Certificate of FCA Liquid Handling, Tecan – Austria
2010 - Bioinformatic Course, Computer Programming Languages and Algorithms in Bioinformatics, Umeå University, Umeå, Sweden
2002 - EMBO Practical Course on Cell Biology – Wageningen, Netherlands

Original Articles

  1. ABUALIA R, ÖTVÖS K, NOVÁK O, BOUGUYON E, DOMANEGG K, KRAPP A, NACRY P, GOJON A, LACOMBE B, BENKOVÁ E. Molecular framework integrating nitrate sensing in root and auxin-guided shoot adaptive responses, PNAS. 2022 Aug 2;119(31):e2122460119. doi: 10.1073/pnas.2122460119. Epub 2022 Jul 25. (2022), IF: 9.4
  2. VEGA A, FREDES I, O'BRIEN J, SHEN Z, ÖTVÖS K, ABUALIA R, BENKOVA E, BRIGGS SP, GUTIÉRREZ RA. Nitrate triggered phosphoproteome changes and a PIN2 phosphosite modulating root system architecture. EMBO REPORTS. 2021 Sep 6;22(9):e51813. doi: 10.15252/embr.202051813. Epub 2021 Aug 6. (2021). IF: 9.071
  3. HAN H, VERSTRAETEN I, ROOSJEN M, MAZUR E, RÝDZA N, HAJNÝ J, ÖTVÖS K, WEIJERS D, FRIML J. Rapid auxin-mediated phosphorylation of Myosin regulates trafficking and polarity in Arabidopsis. bioRxiv. 2021.04. 13.439603. (2021)
  4. ÖTVÖS K, MISKOLCZI P, MARHAVÝ P, CRUZ-RAMÍREZ A, BENKOVÁ E, ROBERT S, BAKÓ L. Pickle Recruits Retinoblastoma Related 1 to Control Lateral Root Formation in Arabidopsis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021 Apr 8;22(8):3862. doi: 10.3390/ijms22083862. (2021). IF: 6.208
  5. ÖTVÖS K, MARCONI M, VEGA A, O'BRIEN J, JOHNSON A, ABUALIA R, ANTONIELLI L, MONTESINOS JC, ZHANG Y, TAN S, CUESTA C, ARTNER C, BOUGUYON E, GOJON A, FRIML J, GUTIÉRREZ RA, WABNIK K, BENKOVÁ E. Modulation of plant root growth by nitrogen source-defined regulation of polar auxin transport. THE EMBO JOURNAL. 2021 Feb 1;40(3):e106862. doi: 10.15252/embj.2020106862. Epub 2021 Jan 5. (2021). IF: 14.012
  6. MONTESINOS JC, ABUZEINEH A, KOPF A, JUANES‐GARCIA A, ÖTVÖS K, PETRÁŠEK J, SIXT M, BENKOVÁ E. Phytohormone cytokinin guides microtubule dynamics during cell progression from proliferative to differentiated stage.THE EMBO JOURNAL. 2020 Sep 1;39(17):e104238. doi: 10.15252/embj.2019104238. Epub 2020 Jul 15. (2020). IF: 11.598
  7. HURNÝ A, CUESTA C, CAVALLARI N, ÖTVÖS K, DUCLERCQ J, DOKLÁDAL L, MONTESINOS JC, GALLEMÍ M, SEMERÁDOVÁ H, RAUTER T, STENZEL I, PERSIAU G, BENADE F, BHALEARO R, SÝKOROVÁ E, GORZSÁS A, SECHET J, MOUILLE G, HEILMANN I, JAEGER G, LUDWIG-MÜLLER J, BENKOVÁ E. SYNERGISTIC ON AUXIN AND CYTOKININ 1 positively regulates growth and attenuates soil pathogen resistance. NATURE COMMUNICATIONS. 2020 MAY 1;11(1):2170. DOI: 10.1038/S41467-020-15895-5. (2020). IF: 14.919
  8. ÖTVÖS K, BENKOVÁ E. Spatiotemporal mechanisms of root branching. CURRENT OPINION IN GENETICS & DEVELOPMENT. 2017 AUG:45:82-89. DOI: 10.1016/J.GDE.2017.03.010 (2017). IF: 5.496
  9. ŠIMAŠKOVÁ M, O´BRIEN JA, KHAN M, VAN NOORDEN G, ÖTVÖS K, VIETEN A, DE CLERCQ I, VAN HAPEREN JMA, CUESTA C, HOYEROVA K, VANNESTE S, MARHAVÝ P, WABNIK K, VAN BREUSEGEM F, NOWACK M, MURPHY A, FRIML J, WEIJERS D, BEECKMAN T, BENKOVÁ E. Cytokinin response factors regulate PIN-FORMED auxin transporters. NATURE COMMUNICATION. 2015 Nov 6:6:8717. doi: 10.1038/ncomms9717. (2015). IF: 11.47
  10. BURÉN S; ORTEGA-VILLASANTE C; ÖTVÖS K, SAMUELSSON G; BAKÓ L; VILLAREJO A. Use of the Foot-and-mouth disease virus 2A peptide co-expression system to study intracellular protein trafficking in Arabidopsis. PLOS ONE. 2012;7(12):e51973. doi: 10.1371/journal.pone.0051973. Epub 2012 Dec 14. (2012). IF: 4.092
  11. SHAIKHALI J, DE DIOS BARAJAS-LOPÉZ J, ÖTVÖS K, KREMNEV D, GARCIA AS, SRIVASTAVA V, WINGSLE G, BAKO L, STRAND A. The CRYPTOCHROME1-Dependent Response to Excess Light Is Mediated through the Transcriptional Activators ZINC FINGER PROTEIN EXPRESSED IN INFLORESCENCE MERISTEM LIKE1 and ZML2 in Arabidopsis. THE PLANT CELL. 24(7):3009-25 (2012). IF: 10.224
  12. BÍRÓ J, FARKAS I, DOMOKI M, ÖTVÖS K, BOTTKA S, DOMBRÁDI V, FEHÉR A. The histone phosphatase inhibitory property of plant nucleosome assembly protein-related proteins (NRPs). PLANT PHYSIOLOGY AND BIOCHEMISTRY: PPB / Société française de physiologie végétale, 52:162-8. (2012). IF: 2.838
  13. FODOR-DUNAI CS, FRICKE E, POTOCKÝ M, DORJGOTOV D, DOMOKI M, JURCA EM, ÖTVÖS K, ŽÁRSKÝ V, BERKEN A, FEHÉR A. The phosphomimetic mutation of an evolutionarily conserved serine residue affects the signaling properties of Rho of plants (ROPs). THE PLANT JOURNAL. 66(4):669-79. (2011). IF: 6.946
  14. ÁBRAHÁM E, MISKOLCZI P; AYAYDIN F, YU P, KOTOGANY E, BAKO L, ÖTVÖS K, HORVÁTH V G, DUDITS D. Immunodetection of retinoblastoma-related protein and its phosphorylated form in interphase and mitotic alfalfa cells. JOURNAL OF EXPERIMETAL BOTANY. 62(6):2155-68. (2010). IF: 4.271
  15. LANTOS CS, GÉMES JUHÁSZ A, SOMOGYI GY, ÖTVÖS K, VÁGI P, MIHÁLY R, KRISTÓF Z, SOMOGYI N, PAUK J. Improvement of isolated microspore culture of pepper (Capsicum annuum L.) via co-culture with ovary tissues of pepper or wheat. PLANT CELL TISS ORGAN CULT. 79(3):285-293. (2009). IF: 1.068
  16. DORJGOTOV D, JURCA ME, FODOR-DUNAI C, SZUCS A, ÖTVÖS K, KLEMENT E, BÍRÓ J, FEHÉR A. Plant Rho-type (Rop) GTPase-dependent activation of receptor-like cytoplasmic kinases in vitro. FEBS LETT. 2;583(7):1175-82. (2009). IF: 3.263
  17. ZSIGMOND L, RIGO G, SZARKA A, SZEKELY GY, ÖTVÖS K, DARULA ZS, MEDZIHRADSZKY FK, KONCZ CS, KONCZ ZS, SZABADOS L. Arabidopsis PPR40 connects abiotic stress responses to mitochondrial electron transport. PLANT PHYSIOLOGY. 146: 1721-1737. (2008). IF: 6.36
  18. PASTERNAK TP, ÖTVÖS K, DOMOKI M, FEHER A. Linked activation of cell division and oxidative stress defense in alfalfa leaf protoplast-derived cells is dependent on exogenous auxin. PLANT GROWTH REGUL. 51,109–117. (2007). IF: 0.841
  19. ÖTVÖS K, PASTERNAK T, MISKOLCZI P, SZUCS A, DUDITS D, FEHER A. Nitric oxide in plants: the cell fate regulator in: Blume Y, Durzan DJ, Smertenko P CELL BIOLOGY AND INSTRUMENTATION: UV Radiation, Nitric Oxide and Cell Death in Plants. IOS Press, (2006) 227-233
  20. SZUCS A, DORJGOTOV D, ÖTVÖS K, FODOR C, DOMOKI M, GYORGYEY J, KALO P, KISS GB, DUDITS D, FEHER A. Characterization of three Rop GTPase genes of alfalfa (Medicago sativa L.). BBA-GENE STRUCT EXPR, 1759, 108-115 (2006). IF: 2.506
  21. FEHER A, ÖTVÖS K. The physiology of somatic embryo induction: A stressful start. in: Hemantaranjan A ADVANCES IN PLANT PHYSIOLOGY Scientific Publishers, (2005) 23-31
  22. ÖTVÖS K, PASTERNAK TP, MISKOLCZI P, DOMOKI M, DORJGOTOV D, SZUCS A, BOTTKA S, DUDITS D, FEHER A. Nitric oxide is required for, and promotes auxin-mediated activation of, cell division and embryogenic cell formation but does not influence cell cycle progression in alfalfa cell cultures. THE PLANT JOURNAL, 43, 849-860 (2005).IF: 6.969
  23. ÖTVÖS K, PASTERNAK TP, DUDITS D, FEHER A. Nitric oxide, a signaling molecule in plant cell reactivation. BMC PLANT BIOLOGY, 5, S1-S27 (2005)
  24. FEHER A, PASTERNAK TP, ÖTVÖS K, DUDITS D. Plant protoplasts: Consequences of lost cell walls. in: MURCH S, SAXENA PK JOURNEY OF A SINGLE CELL TO A PLANT SCIENCE Publishers Inc., (2005) 59-89
  25. DORJGOTOV D, SZUCS A, ÖTVÖS K, SZAKONYI D, KELEMEN ZS, LENDVAI A, DUDITS D, FEHER A. Specific features of RHO GTPase-dependent signalling in plants. CELL BIOLOGY INTERNATIONAL, 27, 191-192 (2003). IF: 1,092
  26. FEHER A, PASTERNAK TP, ÖTVÖS K, MISKOLCZI P & DUDITS D. Induction of embryogenic competence in somatic plant cells: a review. BIOLOGIA BRATISLAVA, 57/1:5 (2002). IF: 0,208

Cumulative IF: 132,852

2016
Teaching assistant, Biology Core Course, ISTA, Klosterneuburg, Austria

2010-2011
Teaching assistant, Molecular and Biochemical Core Course, UPSC, Umeå, Sweden

2005-2006
Teaching assistant, Practical Course in Plant Biology, BRC, Szeged, Ungarn
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