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Johannes Bischof, PhD

Postdoc

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Research statement

I am interested in epidermis and dermis. Until now I was mostly working in the field of skin aging and aging in general. From now on my time will be dedicated to skin disorders, especially to different forms of Epidermolysis bullosa. The most important method employed will be AON-induced exon skipping.

Personal interests

In my spare time I like to go climbing and play board games.

Curriculum Vitae Johannes Bischof

Professional Career

Since 2018
Postdoc at the EB House Austria

2014-2018
Project work for L'Oréal, Paris Lodron University Salzburg

2015-2016
Project work for Stratec Consumables, SALK

 

Education

2017
Dr. rer. nat. in Genetics, Paris Lodron University Salzburg

2012
MSc in Genetics, Paris Lodron University Salzburg

2009
Bakk. rer. nat. in Genetics, Paris Lodron University Salzburg

 

Additional qualifications/training

Project management course

Original Articles

  1. Klermund J, Rhiel M, Kocher T, Chmielewski KO, Bischof J, Andrieux G, el Gaz M, Hainzl S, Boerries M, Cornu TI, Koller U, Cathomen T. On- and off-target effects of paired CRISPR-Cas nickase in primary human cells. Molecular Therapy 2024.
  2. Hainzl S, Trattner L, Liemberger B, Bischof J, Kocher T, Ablinger M, Nyström A, Obermayer A, Klausegger A, Gruber C, Wally V, Bauer JW, Piñón Hofbauer J, Koller U. Splicing Modulation via Antisense Oligonucleotides in Recessive Dystrophic Epidermolysis Bullosa. International Journal of Molecular Sciences 2024.
  3. Illmer J, Zauner R, Piñón Hofbauer J, Wimmer M, Gruner S, Ablinger M, Bischof J, Dorfer S, Hainzl S, Tober V, Bergson S, Sarig O, Samuelov L, Guttmann-Gruber C, Shalom-Feuerstein R, Sprecher E, Koller U, Laimer M, Bauer JW, Wally V. miR-200b-mediated reversion of a spectrum of epithelial to mesenchymal transition states in recessive dystrophic epidermolysis bullosa squamous cell carcinomas. The British journal of dermatology 2023.
  4. Liemberger B, Bischof J, Ablinger M, Hainzl S, Murauer EM, Lackner N, Ebner P, Kocher T, Nyström A, Wally V, Mayr E, Guttmann-Gruber C, Piñón Hofbauer J, Bauer JW,  Koller U. (2023). COL7A1 Editing via RNA Trans-Splicing in RDEB-Derived Skin Equivalents. Int J Mol Sci 24(5):4341.
  5. Zwicklhuber J, Kocher T, Liemberger B, Hainzl S, Bischof J, Strunk D, Raninger AM, Gratz I, Wally V, Guttmann-Gruber C, Piñón Hofbauer J, Bauer  JW, Koller  U (2023). A Novel Fluorescence-Based Screen of Gene Editing Molecules for Junctional Epidermolysis Bullosa. Int J Mol Sci 24(6):5197.
  6. Petković I, Bischof J, Kocher T, March OP, Liemberger B, Hainzl S, Strunk D, Raninger AM, Binder AM, Reichelt J, Guttman-Gruber C, Wally V, Piñón Hofbauer J, Bauer JW, Koller U. COL17A1 editing via homology-directed repair in junctional epidermolysis bullosa. Front Med 2022, 9:976604.
  7. Bischof J, March OP, Liemberger B, Haas SA, Hainzl S, Petković I, Leb-Reichl V, Illmer J, Korotchenko E, Klausegger A, Hoog A, Binder H-M, Garcia M, Duarte B, Strunk D, Larcher F, Reichelt J, Guttmann-Gruber C, Wally V, Hofbauer JP, Bauer JW, Cathomen T, Kocher T, Koller U. Paired nicking-mediated COL17A1 reframing for junctional epidermolysis bullosa. Molecular Therapy 2022.
  8. Kocher T, Bischof J, Haas SA, March OP, Liemberger B, Hainzl S, Illmer J, Hoog A, Muigg K, Binder HM, Klausegger A, Strunk D, Bauer JW, Cathomen T, Koller U. A non-viral and selection-free COL7A1 HDR approach with improved safety profile for dystrophic epidermolysis bullosa. Molecular Therapy - Nucleic Acids, 2021
  9. Bornert O, Hogervorst M, Nauroy P, Bischof J, Swildens J, Athanasiou I, Tufa SF, Keene DR, Kiritsi D, Hainzl S, Murauer EM, Marinkovich MP, Platenburg G, Hausser I, Wally V, Ritsema T, Koller U, Haisma EM, Nyström A. QR-313, an Antisense Oligonucleotide, Shows Therapeutic Efficacy for Treatment of Dominant and Recessive Dystrophic Epidermolysis Bullosa: A Preclinical Study. J Invest Dermatol
  10. Kocher T, March OP, Bischof J, Liemberger B, Hainzl S, Klausegger A, Hoog A, Strunk D, Bauer JW, Koller U. Predictable CRISPR/Cas9-Mediated COL7A1 Reframing for Dystrophic Epidermolysis Bullosa. J Invest Dermatol. 2020, ISSN 0022-202X
  11. Rinnerthaler M, Duschl J, Steinbacher P, Salzmann M, Bischof J, Schuller M, Wimmer H, Peer T, Bauer JW, Richter K. Age-related changes in the composition of the cornified envelope in human skin. Exp. Dermatol. 2013;22(5):329-335.
  12. Bischof J, Salzmann M, Streubel M K, Hasek J, Geltinger F, Duschl J, Bresgen N, Briza P, Haskova D, Sopjani M, Richter K, Rinnerthaler M. Clearing the Outer Mitochondrial Membrane from harmful proteins via LipidDroplets. Cell Death Discov. 2017;3:17016
  13. Auer S, Rinnerthaler M, Bischof J, Streubel MK, Breitenbach-Koller L, Geisberger R, Aigner E, Cadamuro J, Richter K, Sopjani M, Haschke-Becher E, Felder TK, Breitenbach M. The Human NADPH Oxidase, Nox4, Regulates Cytoskeletal Organization in Two Cancer Cell Lines, HepG2 and SH-SY5Y. Front. Oncol. 2017;7(111).
  14. Streubel MK, Bischof J, Weiss R, Duschl J, Liedl W, Wimmer H, Breitenbach M, Weber M, Geltinger F, Richter K, Rinnerthaler M. Behead and live long or the tale of cathepsin L. Yeast 2018;35(2):237-249.
  15. Streubel MK, Neuhofer C, Bischof J, Steinbacher P, Russe E, Wechselberger G, Richter K, Rinnerthaler M. From Mice to Men: An Evolutionary Conserved Breakdown of the Epidermal Calcium Gradient and Its Impact on the Cornified Envelope. Cosmetics 2018;5(2):35.

Reviews

  1. Bischof J, Hierl M, Koller U. Emerging Gene Therapeutics for Epidermolysis Bullosa under Development. International journal of molecular sciences 2024;25:2243.
  2. Kocher T, Petkovic I, Bischof J, Koller U. Current developments in gene therapy for epidermolysis bullosa. Expert opinion on biological therapy 2022:1-14.
  3. Rinnerthaler M, Streubel MK, Bischof J, Richter K. Skin Aging, gene expression and calcium. Exp. Gerontol. 2015;68:59-65.
  4. Rinnerthaler M, Bischof J, Streubel MK, Trost A, Richter K. Oxidative stress in aging human skin. Biomolecules 2015;5(2):545-589.

Book Chapters

  1. Streubel MK, Rinnerthaler M, Bischof J, Richter K. Changes in the Composition of the Cornified Envelope During Skin Aging. Textbook of Aging Skin 2017;ISBN:978-3-662-47397-9.
  2. Bischof J. Lipid droplets im Kontext von zellulärem Stress. Gesund Altern 2018;ISBN: 978-3-658-19972-2.

Other

  1. Kocher T, March OP, Bischof J, Liemberger B, Hainzl S, Klausegger A, Hoog A, Strunk D, Bauer JW, Koller U. CRISPR-Cas9-basierte Korrekturstrategie – vorhersagbare Reparaturergebnisse. Spectrum Dermatologie 2020;04/2020:62-3.

2015-2017
Teacher at a laboratory training course in the field of aging research at the Paris Lodron University Salzburg
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